.Organisation/Company Instituto de Tecnologia Química e Biológica António Xavier ITQB NOVAResearch Field Chemistry » OtherResearcher Profile First Stage Researcher (R1) Positions Master PositionsCountry PortugalApplication Deadline 23 Apr 2025 - 23:59 (Europe/Lisbon)Type of Contract To be definedJob Status Full-timeHours Per Week 35Offer Starting Date 10 Apr 2025Is the job funded through the EU Research Framework Programme?
Not funded by a EU programmeReference Number 029/BI/2025Is the Job related to staff position within a Research Infrastructure?
NoOffer DescriptionApplications are invited for a Master Fellowship in the scope of an internal ITQB NOVA project (IC223011).Scientific Area: Chemistry.Academic degree: Applicants should hold an MSc degree in the areas of Computational Chemistry, Computational Biochemistry, Computational Biology or Computational Physics, with a final score no lower than 16/20.Other requisites:We are looking for a young, highly motivated and creative researcher, looking forward to embracing a challenging project to advance simulation of membrane pores.
Candidates should:have experience in molecular dynamics simulations; have experiencein the simulation of coarse-grained biomolecular systems, preferably of biological membranes; have experiencein the development of coarse-grain molecular dynamic parameters; have experiencewith the Linux operating system and scripting languages such as Python; be interested in developing innovative research and in progressing as scientists; have capacity to supervise younger students; be proficient in spoken and written English; be available tostart in April 2025; be enrolled in a PhD, or in a non-academic degree course, in accordance with the Article 6th of "Regulamento de Bolsas de Investigação da Fundação para a Ciência e a Tecnologia, I.P.
from FCT", law in force.A one-page motivation letter must be included stating the candidate's expertise and motivation for developing this project.Working Plan: The candidate will employ specific simulation and analysis methods to evaluate and further develop the Martini coarse-grained force-field, towards a more realistic description of pore formation in membranes.
The selected candidate will:characterize the current state of the Martini force-field in the formation of pores; identify structural and dynamic determinants responsible for any lack of representativity in pore formation; study pore formation in conjugation with the presence of membrane-active peptides; propose new force-field parameters that bring Martini poration better in line with expected behavior